A case analysis of QT interval prolongation caused by levofloxacin
XU Na
ZHU Man
Abstract：One 87-year-old male patient who had undergone the postoperative esophageal cancer radiotherapy was hospitalized because of cough and expectoration for 20 days. The patient was diagnosed as pulmonary infection and treated with ceftriaxone (2 g, qd, ivgtt) after admission. Eight days later, the lesion of bilateral lung showed by CT examination was aggravated. Then ceftriaxone was changed to imipenem/cilastatin (0.5 g, q 8 h, ivgtt) and levofloxacin (0.5 g, qd, ivgtt) on June 8. During the treatment, the QTc interval was 472 ms showed by electrocardiogram on June 12 and 475 ms on June 15. The QTc interval prolongation was considered as the adverse reactions of levolfoxacin. So the levolfoxacin was stopped on June 18. In the meantime, the QTc interval returned to normal (392 ms) on June 20. The patient's infective indicators improved on June 21, and the imipenem/cilastatin was changed to cefoperazone/sulbactam (3 g, q 12 h, ivgtt) and levofloxacin (0.5 g, qd, ivgtt), then the QTc interval extended to 500 ms three days later. The levolfoxacin was stopped in time. The QTc interval was still 499 ms which did not return to normal on June 27. And the next day, the patient was discharged and the electrocardiogram was no further monitored.
Keywords：LevolfoxacinFluoroquinolonesPulmonary infectionQT interval prolongationAdverse drug reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 63-65 )