Evaluation of the clinical use of intravenous immunoglobulin in pediatric patients
WEN Ai-ping
WANG Wei-na
CHEN Jia-shuai
LI Jia
Abstract：Objective: To review and evaluate the clinical application of intravenous immunoglobulin in pediatric patients. Methods: The data of intravenous immunoglobulin used in pediatric patients were collected from September 2014 to April 2016 retrospectively. The consistency between the primary diagnoses and the label information or pharmacopoeia was evaluated. The beneifts of the off-label use of intravenous immunoglobulin were scored and graded based on the guidelines. The rationality of dosing regimen was evaluated according to the label information, pharmacopoeia and guidelines.Results:A total of 160 pediatric patients were included, and the primary diagnoses of the patients were severe infections, liver transplantation and ABO hemolytic disease of the newborn, 53.74% of which were off-label use. Among the off-label use, intravenous immunoglobulin was probably beneifcial for the patients with liver transplantation, ABO hemolytic disease of the newborn, hemophagocytic lymphohistiocytosis, hematopoietic stem cell transplantation, acute graft-versus-host disease and hemolytic anemia of the newborn. Only 68 patients' dosing regimens were judged as rational according to the label information or guidelines.Conclusion: The rationality of the clinical use of intravenous immunoglobulin in pediatric patients demands to be further veriifed, and the dosing regimen needs to be standardized.
Keywords：Intravenous immunoglobulinPediatric patientsRationality
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 51-55 )