The active surveillance of triazole antifungal agents-induced liver injury

ZHU Man; GUO Mao-wen; GUO Dai-hong; WU Xu; MA Liang; ZHAO Peng-zhi; ZHAO Liang

doi:10.3969/j.issn.1672-8157.2017.01.013

Abstract：Objective: To study the feasibility and key elements of active surveillance of inpatient's drug-induced liver injury on three kinds of triazole antifungal agents based on computer-aided system.Methods: Based on inpatient's active monitor and assessment system of adverse drug events and team work, the event configurator of drug-induced liver injury on triazole antifungal agents was optimized. Retrospective method was used for evaluating the inpatients in PLA general hospital from January 1, 2015 to November 30, 2015 who intravenously used the lfuconazole and sodium chloride injection, voriconazole for injection and itraconazole injection. The positive warning cases were re-evaluated manually.Results: The event monitor conifgurator parameters of plan three were the most reasonable. The screening cases about lfuconazole, voriconazole and itraconazole were 840, 211 and 81 cases, respectively. A total of 377 warning cases of lfuconazole were screened by the system, and after the manual re-evaluation, the actual positive cases and warning rate were 42 cases and 5.00%. 94 warning cases about voriconazole were screened by the system, while the actual positive cases and warning rate were 15 cases and 7.11%. 28 warning cases about itraconazole were screened by the system, and the actual positive cases and warning rate were 4 cases and 4.94%.Conclusion: In this study, we considered diverse criteria to set the parameters of hypohepatia event conifgurator, which was proved excellent maneuverability and elasticity. The loss rate of positive cases was low. Setting parameters of adverse drug events conifgurator was the key point and should be based on different target drugs as well as the characteristics of different adverse drug events.