Analysis on 930 cases of ADR/ADE associated with glycopeptides and oxazolidinone antibacterials from military hospitals
WANG Dong-xiao
ZHU Man
GUO Dai-hong
ZHAO Su-yu
MA Liang
CHEN Chao
ZHAO Peng-zhi
ZHAO Liang
Abstract：Objective: To investigate the characteristics and regular patterns of adverse drug reaction reports and events (ADR/ADE associated with glycopeptides and oxazolidinone based on the analysis of glycopeptides and oxazolidinone antibacterials ADR/ADE from military hospitals, and to provide references for the clinical rational drug use.Methods:A total of 930 ADRs/ADEs of glycopeptides and oxazolidinone antibacterials from 2009 to 2015 were collected from the database of PLA ADR monitoring center. The age and gender of patients, categories of suspected anti-infective drugs, route of administration, systems/organs involved, clinical manifestations, report type, relevance evaluation and prognosis were retrospectively analyzed.Results: Among 930 ADRs/ADEs, the male to female ratio was 1.36 : 1. The average age of the patients was (48.41 ± 24.95) years. Intravenous infusion and injection type were the main administration route and pharmaceutical form, respectively. The ADRs/ADEs were mainly related to glycopeptides antibacterials (768 cases, 82.58%). Four drugs were involved in 930 ADRs/ADEs, and the top 2 drugs in terms of frequency of occurrence were vancomycin (554 cases, 58.49%) and linezolid (162 cases, 17.42%). 930 cases of the ADR/ADE involved multiple systems/organs (994 frequencies). The most common ADRs were the skin and its appendages damage (472 cases, 47.48%), most of which were associated with vancomycin (340 cases, 36.56%). The second was the hematological system damage (156 cases, 15.69%), most of which were associated with linezolid (110 cases, 11.83%).Conclusion: The ADR/ADE induced by glycopeptides and oxazolidinone antibacterials involved different ages of patients and multiple systems/organs. In order to recognize and treat the ADR/ADE in time, risk prevention of drug safety should be strengthened in the application of anti-infective agents.
Keywords：GlycopeptidesOxazolidinoneAnti-infective drugsAdverse drug reactionAdverse drug events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-40,41 )