One case of allergic shock and acute myocardial injury induced by carboplatin injection
SHAO Dan
YU Qian
WANG Hua
Abstract：One 50-year-old female patient was admitted mainly because of postoperative recurrence of ovarian cancer. The patient underwent total resection of the uterus, accessories etc for poorly differentiated serous papillary adenocarcinoma of the ovary two years ago and recevied 8 courses of chemotherapy after that. After admission, carboplatin injection (300 mg, qd, ivgtt) was given to the patient. Ten minutes later, the patient developed dizziness, falling down, transient unconsciousness, palpitations, nausea, vomiting, cold limbs. Carboplatin injection was stopped immediately. And the patient was given oxygen, ECG and blood oxygen monitoring. Vital signs were T 35.5℃, HR 90– 130 times·min-1, R 25–30 times·min-1, BP 60/35 mm Hg, SaO2 60%–70%. ECG test showed that sinus arrhythmia and inferior wall myocardial injury. Then, the patient was given 0.9% sodium chloride injection (500 mL, ivgtt), dexamethasone sodium phosphate injection (10 mg, iv), promethazine injection (25 mg, im), dopamine injection (100 mg, ivgtt). Blood test showed NT-proBNP was 1330 pg·mL-1, CK-MB was 43.9 U·L-1. After 2 hours, the phenomena of nausea and vomiting gradually eased while dizziness and palpitation still existed. BP was 98/54 mm Hg. Dopamine injection was given to the patient continuously. 50 h later, vital signs were BP 100/70 mm Hg, T 36.8℃, HR 74 times·min-1, R 18 times·min-1, the patient's condition improved.
Keywords：Carboplatin injectionAdverse drug reactionAllergic shockAcute myocardial injury
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 389-391 )