One case of exfoliative dermatitis induced by sulbenicillin for injection
MA Li-ping
LIU Bing
LIN Zhan-quan
WANG Hai-ying
GENG Xing-hua
Abstract：One 77-year-old male patient was admitted to hospital for renal dysfunction, peritoneal dialysis for eight months, fatigue and anorexia for 2 days. On the tenth day after admission, sulbenicillin (3 g, ivgtt) was used for lung infection. During infusion, the patient suffered from systemic skin itch, obvious wheezing and dyspnea. The blood pressure was 89/50 mm Hg. Sulbenicillin was stopped immediately, the symptoms of choke and skin itch improved after diphenhydramine (20 mg, im) and dexamethasone (5 mg, ivgtt) treatment. One day later, the patient developed lip blisters, edema, oscheocele and aggravating itch. Cetirizine (10 mg, po) was given to the patient. On the sixth day with sulbenicillin withdrawal, lip mucosa and skins of neck and underarms presented sheet exfoliation. On the eleventh day with drug withdrawal, patient' whole body skin presented exfoliation, compound betamethasone (1 mL, im) was given and the rashes gradually improved. Forty-ifve days after drug discontinuation, the patient's skin was covered with new skin and the systemic skin pigmentation was left.
Keywords：SulbenicillinExfoliative dermatitisAdverse drug reaction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 381-382,383 )