A systematic review of sildenafil citrate in treatment of poor endometrial development
SUN Yang
CHEN Ya-qiong
LAN Xiao-xia
HOU Hai-yan
Abstract：Objective:To systematically review the efficacy of sildenafil citrate in treatment of poor endometrial development.Methods:The randomized controlled trials (RCTs) about sildenaifl citrate used for poor endometrial development disease were searched in PubMed, EMbase,Medline (Ovid),The Cochrane Library, CBM, CNKI, VIP and Wanfang database from the date of their establishment to December, 2014. Two reviewers screened literature, extracted data independently according to the inclusion and exclusion criteria and assessed the methodological quality of pooled studies. Then meta-analysis was performed using RevMan 5.3.Results: A total of 7 RCTs involving 538 patients were included. The results of meta-analysis showed that the sildenaifl citrate was superior to the control group in raising endometrial thickness [MD = 1.33, 95%CI(0.46, 2.21),P = 0.003], as well as clinical pregnancy rates [RR = 3.20, 95%CI(1.95, 5.25),P < 0.000 01], pulsation index (PI) of endometrial spiral artery blood lfow [MD =–0.64, 95%CI(–0.78,–0.51),P < 0.000 01], resistance index (RI) of endometrial spiral artery blood flow [MD =–0.17, 95%CI(–0.21,–0.13),P < 0.000 01]. However, sildenafil citrate showed significant effect on endometrial morphology, blood estradiol level and blood progesterone level (single study only).Conclusion: Sildenaifl citrate showed evident effect in poor endometrial development. Due to limited quality of the included studies, the above mentioned conclusion still needs to be veriifed by conducting more high quality blinding RCTs.
Keywords：Poor endometrial developmentSildenaifl citrateSystematic reviewMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 333-337,352 )