Evaluation of rational drug use in 9441 cases of compound trivitamin B for injection(Ⅱ)

LI Xin; YU Qian; WANG Hua

Abstract：[AbstrAct]Objective: To analyze the utilization of compound trivitamin B for injection (Ⅱ) used in our hospital, and ifnd out the regulation and characteristics of irrational drug use and ADR/ADE, and provide references for clinical rational drug use.Methods: A retrospective study was conducted to evaluate 9441 cases of compound trivitamin B for injection (Ⅱ) in solvent, dosage and 22 cases of ADR/ADE reported to the National Adverse Drug Reaction Monitoring Center.results: Over drug instructions using solvent and dosage cases were 2291 and 403 respectively, accounted for 28.54%. The 22 ADR/ADE cases occurred between 2014 and 2015 were mainly involved in the skin and its appendages (37.50%) and systemic damage (25.00%), in which 8 ADR/ADE cases (36.36%) were caused by ultra manual, severe ADR/ADE showed dififculty in breathing, urinating dififculty and body numbness, which the instructions are not prompted.conclusion:According to solvent and dosage instructions provided for the use of compound trivitamin B for injection (Ⅱ) , and paying attention to the risk of adverse reactions which not mentioned in speciifcation will reduce the occurrence of serious ADR/ADE.