One case of severe agranulocytosis induced by methimazole
TAO Li-na
QU Xiao-yu
ZHANG Si-xi
SONG Yan-qing
Abstract：One 21-year-old female patient with a history of hyperthyroidism for 2 years had received methimazole therapy (10 mg thrice daily) for 1 year. One year ago, she stopped methimazole because of fever, and switched to therapy with propylthiouracil. Due to poor treatment effect, she reapplied methimazole therapy (10 mg thrice daily) 3 weeks ago. The patient had a fever and cough 2 days before hospitalization. Blood routine examination showed leucopenia with neutropenia. White blood cell count was 0.3 × 109·L-1, and the absolute neutrophil count was 0.04 × 109·L-1. She had a fever, and was diagnosed with neutropenia. Methimazole was stopped. Recombinant human granulocyte colony-stimulating factor, batyl alcohol and leucogen were provided to elevate white blood cell, and antibiotics were also given. White blood cell count recovered to normal range on the 9th day. The symptoms also resolved.
Keywords：MethimazoleHyperthyroidismAgranulocytosisAdverse drug reaction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 258-260 )