One case of acute renal injury caused by pleural infusion of cisplatin chemotherapy in lung cancer patient
YANG Lei
WANG Lin-hai
LIN Yi-ju
ZHAO Qi-zou
NIE Cai-xia
ZOU Zhi-mu
YIN Si-min
Abstract：A 60-year-old female lung cancer patient with pericardial cavity metastasis was admitted to hospital. The patient had a history of high blood pressure and diabetes. The indicators of renal function were normal at the first day of admission and before cisplatin pleural infusion chemotherapy. The patient was treated with pleural infusion chemotherapy for 3 times (cisplatin 90 mg + recombinant human endostatin injection 30 mg), the results of renal function showed acute renal injury on the second day and the fifth day after cisplatin pleural infusion chemotherapy. Clinical pharmacists analyzed the possible reasons of acute renal injury from the patient's physical condition, original disease, adverse drug reaction, and mechanism of drug action. Clinical pharmacists considered that the reason was more likely due to the cisplatin, and suggested stopping cisplatin immediately. Rehydration therapy (about 3000 mL·d-1) was given to the patient for 3 days,Shenshuaining tablets (6 tablets, tid) andJinshuibao capsules (6 capsules, tid) for adjuvant treatment were given to the patient for 12 days. Clinical pharmacists told the patient to drink more water for promoting drug elimination. After symptomatic treatment, the results showed that the renal function restored to normal a week after discharged from hospital.
Keywords：CisplatinPleural infusion chemotherapyAcute renal injuryClinical pharmacistAdverse drug reaction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 255-257,258 )