Bibliometric analysis of the resistance mechanisms ofCandida albicans from 1970 to 2015

LI De-dong; GUAN Shao-xing; HU Jing; SHAN Wen-zhi; LIU Ping; SUN Yan

Abstract：Objective:To investigate and analyze the literature of resistance mechanisms ofCandida albicans by bibliometric methods, in order to improve the knowledge of resistance mechanism.Methods:All literature about the drug resistance mechanisms ofC.albicans were collected in PubMed, Embase, SCI and CNKI databases. Statistical analysis was carried out on the publication date, authors, languages, types of literature, types of antifungals, drug resistance mechanisms of the included studies. Results:A total of 726 papers were collected from the four databases. The amount of literature has increased year by year since the 1990s. The amount of English literature was the most (466), while the number of Chinese literature increased rapidly in recent years (197). The overall level of Chinese related researches was low but there were some highlights. Azoles were the most studied antifungals (357), and lfuconazole related papers had the largest number (236). Researches on the drug resistance mechanisms were mainly focused on the expression changes of drug eflfux pumps and the structural variation or the content changes of the target enzyme.Conclusion:Azoles resistance is still the key point in the research ifeld of drug resistance ofC.albicans. The main drug resistance mechanisms ofC.albicans are the upregulation of the expression of drug eflfux pumps and the structural variation or the content increase of the target enzyme.