Adjustment of therapeutic regimen for an acute myocardial infarction patient with small intestinal stromal tumor
ZHANG Xin-ru
WANG Dong-xue
CHEN Ya-dan
FU Xiu-juan
Abstract：A 60-year-old male patient with acute ST-segment elevation myocardial infarction was admitted to hospital. This patient received imatinib orally because of small intestinal stromal tumor for 7 years. Imatinib is metabolized by the cytochrome P450 and transport protein P-glycoprotein, and imatinib can inhibit the activity of CYP3A4, CYP2D6, CYP2C9, CYP2C19 and P-glycoprotein. So imatinib has the potential interaction with many drugs used for the treatment of acute myocardial infarction. Pharmacists suggested replacing atorvastatin to rosuvastatin, enalapril to ramipril, and clopidogrel to ticagrelor for avoiding potential drug interaction, respectively. At the same time, pharmacists provided pharmaceutical care and medication guide to the patient. After symptomatic treatment, the patient was discharged with a better health condition.
Keywords：Acute myocardial infarctionImatinibTherapeutic regimenDrug interactionsClinical pharmacist
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 221-223 )