A case of anaphylactic shock caused by carboprost tromethamine injection

LU Ying-rong; SONG Hui-zhu; CAI Xiao-jun

Abstract：A 33-year-old female was hospitalized for awaiting delivery. She was diagnosed as gestational diabetes during pregnancy. Lower uterine segment cesarean section with lumbar anesthesia operation was applied after admission. During the operation, 250 μg carboprost tromethamine was injected into uterus body for promoting uterine contraction. Five minutes later, the patient developed numbness of mouth and tongue, dripping great sweat, breathing deepened to speed up, humidicool limbs and other symptoms. ECG monitoring indicated that heart rate was 100 times per minute, blood pressure dropped to 80/53 mm Hg (1 mm Hg = 0.133 kPa), which was considered as drug-induced anaphylactic shock. Subcutaneous injection of 1 mg adrenaline and antiallergic treatment with 10 mg dexamethasone sodium phosphate were given through intravenous injection, and metaradrine was given to elevate blood pressure immediately. About 30 minutes later, ECG monitoring of the patient indicated that heart rate was 90 times per minute, blood pressure increased to 107/76 mm Hg, breathing rate was 20 times per minute. The patient recovered with smooth breath, blushed lips and warmer limbs.