A case analysis of thrombocytopenia caused by tigecycline off-label use
ZHANG Hong-cui
WANG Xiao-wei
ZHU Man
Abstract：One 82-year-old female patient combined with a variety of basic diseases was hospitalized because of pulmonary infection. Several results of sputum culture conifrmed Acinetobacter baumannii infection and tigecycline (100 mg, q 12 h, ivgtt) was administered for anti-infective therapy. Eight days later, the patient appeared drug-induced thrombocytopenia. About 11 days after tigecycline therapy, lansoprazole and low-molecular-weight heparins calcium which may cause thrombocytopenia were discontinued. About 19 days after tigecycline therapy, the patient's pulmonary infection was in stable condition but her platelets declined to 42 × 109·L-1, tigecycline was discontinued due to the thrombocytopenia. Five days later, the patient's platelets gradually returned to 102 × 109·L-1, and the patient was discharged after 33 days' hospitalization.
Keywords：TigecyclinePulmonary infectionThrombocytopeniaAdverse drug reaction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 125-127 )