Application analysis on antidepressant drugs of 22 hospitals in Beijing from 2010 to 2014

CHEN Rui-ling; ZHAO Zhi-gang; WANG Ya-jie

Abstract：Objective:To investigate the status and the development tendency of clinical application of antidepressants in Beijing area, and provide evidence for rational usage of antidepressants. Methods: Using the analytical method of the deifned daily dose (DDD) recommended by WHO, consumption sum, DDDs and deifned daily cost (DDC) of antidepressants in 22 hospitals in Beijing area from 2010 to 2014 were analyzed retrospectively.Results:Within 5 years, 19 kinds of antidepressants were used. DDDs and consumption sum of antidepressants showed increased trend year by year in 22 hospital of Beijing. Average annual growth rates of consumption sum and DDDs were 14.79%and 16.47%respectively. DDC remained unchanged. Selective serotonin reuptake inhibitors (SSRIs), selective serotonin and norepinephrine reuptake inhibitors (sSNRIs) used predominantly. The consumption sum of SSRIs and sSNRIs accounted for over 60%–70%and 20%among the total consumption sum of antidepressant drugs respectively. The top 3 drugs in DDDs were paroxetine, lfupentixol and melitracen compound tablets, citalopram or escitalopram. Conclusion:Antidepressant drugs played an increasingly important role in clinical treatment. New types of antidepressants, such as SSRIs and sSNRIs, have already become the ifrst-line antidepressants in clinic practice.