Evaluation of the preventative effect of clindamycin against surgical site infections in perioperative period via the changes of drug-resistance to the target bacteria
SHI Hui-qing
YONG Xiao-lan
HU Ting-ting
Abstract：Objective:To evaluate the preventative effect of clindamycin against perioperative surgical site infections via analyzing the changes of drug-resistance of the target bacteria.Methods:Susceptibility rate and resistance rate ofStaphylococcus andStreptococcus strains which were isolated during 2010–2013 in our hospital against clindamycin were determined according to CLSI methods. All the references issued by Mohnarin and CHINET about the resistance ofStaphylococcus andStreptococcus strains against clindamycin and vancomycin were retrieved through CNKI databank.Results:In our hospital, 64% and 77%ofStaphylococcus andStreptococcus isolates were resistant to clindamycin, respectively. And these data were 57% and 70% in Mohnarin, and 49% and 75% in CHINET, respectively. No isolate was resistant to vancomycin.Conclusion: The resistance rate of clindamycin to the target bacteria is high, the value for perioperative prophylaxis should be further evaluated and discussed.
Keywords：ClindamycinResistanceStaphylococcusStreptococcusPerioperative period
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 376-379 )