Investigation and analysis of the use of proton pump inhibitors in inpatients

LUO Hong-li; XIAO Shun-lin; WEI Qi-ming

Abstract：Objective:To investigate the use of proton pump inhibitor (PPI) in inpatients and provide the references for rational drug use in clinic.Methods: The hospital information system (HIS) was used to count the total number of hospitalization, the use times of PPI and sales amount of drugs in 2014 by retrospective investigation. Then 500 medical records (50 cases per department) were extracted randomly from the top 10 departments in terms of the use of PPI and the rationality of PPI use in respect of indication, drug selection, timing, dosage, frequency, administration route, menstruum, drug combination and course was analyzed. Results: In 108 300 records, the percent of using PPI was 35.59%, the amount of sales of PPIs accounted for 4.49% of the total amount of drug sales. The most use times and sales amount were omeprazole for injection in PPIs. The numbers of irrational PPI use were 308 (61.60%) in 500 sampling medical records. Unreasonable phenomena included non-indication, unsuitable administration route, unsuitable frequency and long duration of medication.Conclusion: There were many irrational PPI uses in inpatients in our hospital. The clinicians should weigh pros and cons, and normalize administration of PPIs so as to reduce the drug-induced risks.