Therapeutic drug monitoring in a patient with severe adverse reactions induced by capecitabine
LI Ran
JIAO Yuan-yuan
LIU Ying
MA Xu
ZHANG Yan-hua
Abstract：We reported a case of severe adverse effect after capecitabine administration. This patient experienced severe mucous toxicity and multiple organ dysfunctions. In order to ifgure out the causes of this severe toxicity, therapeutic drug monitoring (TDM) analysis of serum 5-FU was conducted to determine capecitabine exposure by clinical pharmacists. The serum 5-FU level was 181 ng·mL-1 3 weeks after capecitabine discontinuation, which implied the existence of metabolic dysfunction of capecitabine in this case. Thus, clinical pharmacists suggested using of hemoifltration for eliminating the excess of 5-FU. The toxic symptoms gradually improved after hemoifltration. In this case, clinical pharmacists provided pharmaceutical care on TDM analysis, critical information in determining the causation between drug exposure and toxicity as well as specific treatment regimen. After the symptomatic treatment, the patient was discharged with the improved condition.
Keywords：CapecitabineBlood drug concentrationTherapeutic drug monitoringAdverse drug reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 354-356 )