Correlation study between CYP2C19 gene polymorphisms and clopidogrel resistance in PCI postoperative patients
PENG Wen-xing
XU Xiao-yu
SHI Xiu-jin
LIN Yang
Abstract：Objective: To explore the relationship between clopidogrel resistance and CYP2C19 gene polymorphisms. Methods:A total of 444 cases diagnosed as acute coronary syndrome (ACS) and treated with PCI were retrospectively selected from March 2006 to April 2015. The platelet aggregation rate induced by ADP more than 46% was defined as the clopidogrel resistance, and platelet aggregation rate of 46% or less was defined as sensitive to clopidogrel. Comparison of genotype differences between two groups and risk of clopidogrel resistance among different genotypes were analyzed.Results:CYP2C19*2 or *3 heterozygote mutations in ACS patients were associated with a significant increase the risk of clopidogrel resistance compared with CYP2C19*1/*1. CYP2C19*2/*2 and *2/*3 were at higher risk of clopidogrel resistance. Platelet aggregation rates of *1/*2、*2/*2 and *2/*3 were significantly higher than that of *1/*1 genotype.Conclusion: CYP2C19*2 or *3 mutations were associated with clopidogrel resistance in ACS patients. The rate of platelet aggregation increased with the increase of the number of mutant gene loci of CYP2C19*2 and *3.
Keywords：ClopidogrelGene polymorphismCYP2C19Acute coronary syndrome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 334-338 )