One case of serious delayed hypersensitivity reaction induced by paclitaxel for injection
ZHAO Ji-hong
HOU Dong-dong
MA Li-ping
SHEN Si-jing
Abstract：One 57-year-old female lung cancer patient with lymph node enlargement and facial edema was admitted to hospital. After pretreatment of dexamethasone, paclitaxel (30 mg, ivgtt, st) was given to her and then paclitaxel (90 mg, ivgtt, qd) followed. Seventeen hours later, the patient developed chest and back itching, nausea and scattered miliary plum macula in prothorax. The rash spreaded all over the body even after the antianaphylactic treatment with diphenhydramine (20 mg, im), cetirizine (10 mg) and calamine lotion. And then chlorpheniramine (4 mg), diphenhydramine (20 mg, im) and hydrocortisone sodium succinate (400 mg, ivgtt) were given to her. The patient was getting better gradually and the rash disappeared 18 days later.
Keywords：PaclitaxelDelayed hypersensitivity reactionRashAdverse drug reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 321-323 )