Analysis on dosage adjustment of antibacterials in CRRT patient with septic shock
XU Jin-long
MA Wei-cheng
CAI Yun
CHEN Wu
HU Dong-jun
WANG Xiong-xiong
Abstract：One 70-year-old male patient with fever was diagnosed as cerebral infarction combined with severe pneumonia, septic shock, acute renal failure, chronic subdural hematoma. The patient was treated with imipenem and cilastatin combined with linezolid for anti-infection. Bedside continuous renal replacement therapy (CRRT) was executed and the dose of imipenem and cilastatin was adjusted due to the decreasing of the urine volume and the increasing of serum creatinine. Then the patient developed epilepsy, anti-epileptic treatment was executed, and imipenem and cilastatin and linezolid were withdrawn. Piperacillin and tazobactam was used for anti-infection treatment. Antifungal therapy was added according to the blood culture results. During the treatment, clinical pharmacists gave advice on adjusting the dose of antibiotics when the patient undergoing CRRT, especially for the dosage adjustment of imipenem and cilastatin and selection of antifungal drugs. After symptomatic treatment, the patient was discharged with better condition.
Keywords：Continuous renal replacement therapy (CRRT)Septic shockAntibacterial drugs
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 255-257 )