Bibliometric analysis of CNS infection treated with intraventricular or intrathecal injection of antibiotics

LIU Xu; LI Yue; CAI Yun; WANG Rui; WANG Jin

Abstract：Objective: To investigate the treatment with intraventricular or intrathecal injection of antibiotics for CNS infection based on a bibliometric approach and provide reference for anti-infection researchers.Methods: We searched PubMed, SCI, Embase, CNKI database, etc. EndNote 6.0 software was used to sort these articles from the publication year, corresponding author, literature type, cited frequency, etc. Cause of CNS infection, main diseases, symptoms, route of infection, treatment status, the difference between traditional treatment methods and intraventricular or intrathecal injection of antibiotics were analyzed. Results: A total of 1737 papers were collected, 540 papers met the inclusion criteria, distributed over 355 kinds of journals.Journal of Antimicrobial Chemotherapy was the top in respect of the published paper numbers. The numbers of literature showed an overall upward trend, meanwhile the case report and review were the main type of literature. The highest cited frequency of paper was 560. The top nation with published paper numbers was the United States, following by England and Japan.Conclusion:The treatment by intraventricular or intrathecal injection of antibiotics in CNS infection with higher concentration and good efifcacy attracts more attention for its avoiding the blood-brain barrier impact. While the effect was only reported by case report, high quality randomized controlled clinical trials are needed to conifrm its therapeutic effect.