Prescription analysis on abnormal rise of INR in patients taking warfarin due to drug interactions
SUN Yan
TIAN Fang-yuan
PEI Fei
Abstract：Objective:To investigate the utilization of warfarin and provide reference for rational drug use.Methods:By retrospective analysis, the warfarin orders and the number of INR in our hospital were obtained from April 2013 to April 2014. According to 2014 AHA/ACC/HRS guideline for the management of patients with atrial ifbrillation, the target of INR in patients with atrial ifbrillation and valve replacement surgery are 2.5 to 3.5, the INR > 3.5 as outliners and the reasons were analyzed. Results:The number of warfarin orders in our hospital during April 2013 and April 2014 was 41 615 items, the monitoring number of INR was 2134 cases, the unusual high value of INR was 145 cases, excluding the factor of dose adjustment, 43 cases of them were caused by drug interaction. The drug interaction plays an important role in the abnormal rise of INR in patients taking warfarin. Conclusion:Warfarin could be influenced by many drugsin vivo, which may cause the abnormal rise of INR. When we use warfarin in clinic, we should pay attention to drug interactions to ensure the drug safety of patients.
Keywords：WarfarinDrug interactionInternational normalized ratio (INR)Rational drug use
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 239-241 )