Analysis of the clinical application of magnesium isoglycyrrhizinate injection in 236 patients

ZHOU Hong; WANG Hua-guang; YU Xiao-jia; LIU Li-hong

Abstract：Objective: To investigate and analyze the application of magnesium isoglycyrrhizinate injection in clinic, and provide the reference for rational drug use.Methods: The data of the in-patients who were treated by magnesium isoglycyrrhizinate injection in April 2014 by the hospital information system were collected and analyzed in respect of the indication, usage and dosage, therapeutic regimen and adverse reactions, etc.Results:The majority disease of 236 patients using magnesium isoglycyrrhizinate injection was hepatobiliary system disease accompanied with liver dysfunction, accounting for 43.22%. Most of the remedies were using magnesium isoglycyrrhizinate injection alone (71.61%); daily dose ranged from 0.10 g to 0.20 g, and most of the dose was 0.20 g (70.34%). The mean serum potassium concentration of 115 patients before and after treatment was (4.03 ± 0.57) mmol·L-1and (3.79 ± 0.59) mmol·L-1 respectively (t = 3.421,P = 0.001). The difference was statistically signiifcant.Conclusion:The application of magnesium isoglycyrrhizinate injection in our hospital on the whole was rational, but we should pay attention to the choice of solvent, adjust the dosage according to the liver function and monitor the serum potassium concentrations when using the magnesium isoglycyrrhizinate injection. The rationality of prophylaxis indication should be further evaluated.