Analysis on 32 cases of kidney injury induced byLongdanxiegan pills

Abstract：Objective: To analyze the adverse drug reaction of kidney injury induced byLongdanxiegan pills and provide reference for clinical rational use of drugs.Methods:According to WHO evaluation criterion, a total of 32 cases of kidney injury induced byLongdanxiegan pills in our hospital from 2004 to 2014 were collected and analyzed in respect of age and gender distribution, duration and dose of drug administration, primary disease, causality, laboratory tests and other tests, ADR clinical manifestation, therapeutic method, etc.Results:The evaluation of 32 cases were possibility, including 26 female cases (81.25%) in severe ADRs. The average age was (54.72 ± 8.61) years. The average medication duration was (6.55 ± 4.48) years (from 0.2 to 17 years). The average Scr was (532.2 ± 246.7) μmol·L-1, BUN was (120.80 ± 6.80) mmol·L-1, Hb was (87.59 ± 18.34) g·L-1. The main clinical manifestations were deifciency of both qi and yin in spleen and kidney. The recovery rate was 90.63% with integrated traditional Chinese and western medicine treatment.Conclusion:The cases of kidney injury induced byLongdanxiegan pills containing manchurian dutchmanspipe stem were immeasurable. The age range of the patients was from 50 to 69 years. The number of female patients was more than that of male patients. The medication duration and dosage of drug administration were not on a completely parallel with the degree of renal function impairment and anemia. There were individual differences in the cases of kidney irreversible injury induced byLongdanxiegan pills.