Effect of rosuvastatin on the levels of endothelin and inflammatory factors in hypertension and hyperlipemia patients with different ages
XUE Wen-xin
ZHANG Ai-zhen
XU Hui
KANG Wan-li
ZHAI Ying-li
WANG Chun-ling
LI Jing
Abstract：Objective:To investigate the effects of rosuvastatin on endothelin and inflammatory factors in hypertension and hyperlipemia patients with different ages.Methods:Using prospective cohort study, 132 outpatients with hypertension and hyperlipemia, including 42 young patients, 49 middle-aged patients and 41 elderly patients, were assigned to receive 10 mg·d-1 of rosuvastatin and conventional antihypertensive drugs for 8 weeks. Serum hs-CRP, ET-1 and IL-6 level were measured at baseline and 8 weeks later for statistical analysis.Results:The levels of serum lipid, hs-CRP and IL-6 were improved signiifcantly, after the treatment of rosuvastatin for 8 weeks, while the level of ET-1 did not change signiifcantly. Deducting the inlfuence of baseline level, the levels of serum lipid, inlfammatory markers (hs-CRP and IL-6 level) of each age group treatment had no signiifcant differences after the treatment of rosuvastatin.Conclusion:The effect of lipid-lowering efifcacy and reducing inlfammatory factors (hs-CRP, IL-6) of rosuvastatin had no difference among young, middle-aged and elderly patients with hypertension combined with hyperlipemia.
Keywords：HyperlipemiaRosuvastatinAgingEndothelial functionC-reactive protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 137-140 )