Retrospective evaluation of adverse drug reactions induced by everolimus in advanced cancer patients
WANG Jian-wei
TAO Hai-tao
WANG Jin-liang
DONG Wei-wei
LI Rui-xin
HU Yi
Abstract：Objective: To observe the characteristics and regularities of the adverse drug reactions (ADRs) induced by everolimus, in order to provide reference for clinical application. Methods: A total of 72 patients in our hospital from June 2013 to June 2014 were included. ADRs induced by everolimus were collected and analyzed in respect of sex, age of the patients, entity, ECOG score, condition of drug use, organs or systems involved in ADRs, clinical manifestations, sequelae and other relavant information. Results:The everolimus was applied in a method of increasing the dose gradually. There were 112 ADRs in 72 patients, among which, the percentage of digestive system accounted for the highest (40.18%), and follwed by respiratory system (23.21%); the grade 1 –2 ADR accounted for 82.14%; the most common grade 3 –4 adverse reactions were cough (3.57%), stomatitis (2.68%), diarrhea (1.79%); 62.50% of ADRs occurred within 2 weeks. In respect of sequelae, 80.56% (58/72) of the patients recovered with supportive care, 4 cases had to reduce the dose and receive speciifc treatment;10 cases improved after drug withdrawal. Conclusion: By increasing the dose of everolimus gradually, the drug was well tolerated. Since ADRs induced by everolimus were slight, all the ADRs were well managed.It is important to enhance follow-up observations of patients to prevent some serious ADRs.
Keywords：EverolimusAdverse drug reactionsRational drug useAnalysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 101-104 )