Investigation of the interaction between sertraline and antiplatelet drugs through a patient of repeated in-stent thrombus with depression
ZHANG Qing-xia
YAN Su-ying
PEI Fei
LI Dan-dan
Abstract：One elderly male patient with repeated in-stent thrombus was hospitalized for unstable angina pectoris, inferior and anterior old myocardial infarction. Triple intensive antiplatelet therapy (aspirin 75 mg, qd+ticagrelor 90 mg, bid+cilostazol 50 mg, qd) and other routine treatment were performed simultaneously after admission, but the patient still felt attacks of reoccurrent angina. The patient was diagnosed as depression by the neurologist and was given sertraline hydrochloride (25 mg, qd). Clinical pharmacists paid more attention to the drug interaction between sertraline and antiplatelet drugs. Gingival bleeding happened 10 days after combination use of sertraline and antiplatelet drugs. Considered as the interaction between sertraline and antiplatelet drugs, ticagrelor and cilostazol, sertraline was immediately stopped, meanwhile thrombin and Yunnan baiyao capsules were applied on gum locally. Gingival bleeding was stopped till the next day. Because sertraline and some antiplatelet drugs would interact with each other, the two categories of drugs should be selected cautiously and monitored closely.
Keywords：SertralineAntiplatelet drugsTicagrelorCilostazolInteraction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 85-87 )