Pharmacokinetics of hydrocodone tartrate tablets in human
HAO Guang-tao
QU Heng-yan
ZHANG Li-juan
LI Yuan-yuan
GAO Hong-zhi
DONG Rui-hua
WANG Xiao-fang
LIANG Yu-guang
ZHANG Yuan-yuan
LIU Ze-yuan
ZHANG Hong
Abstract：Objective:To study the pharmacokinetics of hydrocodone tartrate tablets in human. Methods:We carried out single dose, parallel design study. Subjects were divided into three groups according to the dose of 5 mg, 10 mg, 15 mg (low, medium, high), and each group contained ten subjects. HPLC-MS/MS method was used for analysis of hydrocodone and its two metabolites (demethylation of hydrocodone and hydromorphone). WinNonlin 6.1 software was used to calculate the pharmacokinetic parameters. Results:Linearity was established in the range of 0.05–50.00μg·L-1 for hydrocodone and demethylation of hydrocodone, and 0.01–10.00μg·L-1 for hydromorphone. After the oral dose of hydrocodone tartrate tablets, Cmax, AUC0-t and AUC0-∞increased with the dose and showed a good linear relationship. There were no serious adverse events during the course of this study. Conclusion:HPLC-MS/MS is a sensitive and accurate method, which is suitable for the analysis of hydrocodone and its two metabolites (demethylation of hydrocodone and hydromorphone) in plasma and the pharmacokinetics study of hydrocodone tartrate tablets in human.
Keywords：Hydrocodone tartratePharmacokineticsHPLC-MS/MSBlood drug concentration
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 76-81 )