Analysis on 953 ADR reports of our hospital from January 2012 to December 2013

MIAO Qiu-li; YAN Hui-yu; ZHANG Si-xi; SONG Yan-qing

Abstract：[ABSTRACT]Objective:To investigate the feature and regularity of adverse drug reactions (ADRs) occurred in our hospital and provide reference for rational medication in clinic.Methods:A total of 953 ADR reports were collected and retrospectively analyzed from January 2012 to December 2013. The reports were classiifed and analyzed statistically in respect of the age and gender distribution of the patients, route of administration, the category of drugs, organs or systems involved in ADRs and main clinical manifestations, types and outcomes of ADRs, etc.Results: Among the 953 ADR cases, 458 cases (48.06%) were male and 495 cases (51.94%) were female. Totally 192 patients (20.15%) were 51 – 60 years old. Most of the ADRs were induced by anti-infective drugs (mainly in cephalosporins), and follwed by antitumor drugs; the main administration route was intravenous drip, accounting for 71.14%; most of ADRs commonly involved in digestive system, accounting for 40.20%. Moderate ADRs accounted for 98.22%, most of them were improved or cured. There were 2 new ADRs and 15 serious ADRs, including 11 cases of sequela, 1 case of lamotrigine-related death.Conclusion: Great importance should be attached to ADR monitoring and reporting, to reduce or avoid the occurrence of ADR, and promote rational drug use.