Analysis and evaluation of the active monitoring data from five hospitals by ADE warning systems for hospitalized patients
GUO Dai-hong
CHEN Chao
MA Liang
YONG Xiao-lan
ZHANG Mei
FU Gui-ying
XIA Pei-yuan
WEN Ai-dong
ZHU Man
XU Yuan-jie
Abstract：[ABSTRACT]Objective:Active monitoring of key categories of medicine and important event were conducted in multicenter military medical institutions. Characteristics of active monitoring, regularity and related factors about the ADE active monitoring were evaluated to improve technology for drug safety monitoring.Methods: The trained senior clinical pharmacists from ifve pilot hospitals collected the warning data through ADE active monitoring and assessment warning systems for hospitalized patients from January to June in 2014. ADE positive cases were analyzed, classiifed and summarized.Results: The active monitoring positive predictive values of the four ADEs (liver damage, kidney damage, anemia, thrombocytopenia) were (78.93 ± 24.97)%, (46.45 ± 32.81)%, (46.00 ± 36.47)%, (41.27 ± 31.14)%, respectively. Because the case ruled out rate was too high and could not cover the majority of patients with medication, the rate of ADE was correspondingly high. The researchers actively monitored twenty-two pairs of expand drugs, mainly multiple drugs correspond to the one ADE, and also the one drug corresponds to multiple ADEs. The result showed that positive predictive value of expand drugs was generally higher than that of conventional drugs.Conclusion:The system has realized the "real-time monitoring" and "prevention ifrst" drug risk control mode, which provides new methods for effective prevention of clinical medicine risk and reducing ADE damage in the age of big data. As a practical tool, this system can help clinical pharmacist to actively monitor key categories of medicine more efifciently.
Keywords：Adverse drug eventActive monitoringAutomatic warningIntensive monitoring
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 368-371 )