Monitoring of blood concentrations of illegally added western medicine ingredients in traditional Chinese antiepileptic medicines
LI Fang
WANG Dan
WU Cheng
WANG Ling
LI Cheng-min
TONG Wei-hang
Abstract：[ABSTRACT]Objective:To determine blood concentration of illegally added western medicine ingredients in traditional Chinese antiepileptic medicines.Methods:The blood drug concentrations of valproic acid, carbamazepine, phenobarbital and phenytoin were determined by enzyme-linked immunoassay with fully automatic biochemical analyser. Results:Four kinds of western medicine ingredients above were detected in all the patients with traditional Chinese antiepileptic medicines. There were 17 cases of valproic acid and blood drug concentrations within the effective range accounted for 23.53%; 17 cases containing carbamazepine and blood drug concentrations within the effective range accounted for 17.65%; 17 cases containing phenobarbital and blood drug concentrations within the effective range accounted for 41.18%; 5 cases containing phenytoin and blood drug concentrations within the effective range accounted for 60.00%.Conclusion:This method is very easy to determine illegally added western medicine ingredients in traditional Chinese antiepileptic medicines, which can guide the patients for rational drug use in clinic.
Keywords：Antiepileptic drugTraditional Chinese medicineWestern medicine ingredientBlood drug concentration
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 345-347 )