Investigation of the drug interaction between voriconazole and tacrolimus through a renal transplant recipient with pulmonary infection
HUANG Cui-li
GUO Dai-hong
ZHU Man
WANG Dong-xiao
MU Yan
Abstract：One female patient with renal transplant was admitted into hospital for pulmonary infection. After admission, the patient received the concomitant administration of voriconazole and tacrolimus (FK506). Clinical pharmacists paid more attention to the drug interaction between voriconazole and FK506, and monitored closely the blood drug concentration of FK506. During the combination use of voriconazole and FK506, the concentration of FK506 markedly increased. In order to obtain good therapeutic effect and avoid adverse drug reactions, the dose of FK506 was adjusted to 1/4 of the initial dose with the participation of the clinical pharmacists through the monitoring of blood drug concentration. Therefore, the blood drug concentration of FK506 should be monitored closely, the dose of FK506 should be adjusted in consideration of the drug interaction between voriconazole and FK506.
Keywords：VoriconazoleTacrolimusDrug interactionBlood drug concentration
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 291-293 )