Investigation of the interaction between crizotinib and opioid analgesics through a lung cancer patient with pain
WANG Wei-lan
ZHANG Chao
ZHU Man
Abstract：One male lung cancer patient with pain was hospitalized for left lung adenocarcinoma with multiple bone metastases more than one year. Crizotinib and opioid analgesics were taken simultaneously by the patient after admission. Clinical pharmacists analyzed drug interactions, clinical significance and prevention measures between crizotinib and opioid analgesics according to relevant reference data. According to research literature, we inferred a small dose slow-release fentanyl transdermal patches which only play analgesic role produced small possibility of clinical signiifcance by the impact of crizotinib. The patient didn't appear respiratory depression symptoms and constipation significantly reduced when he was administrated with fentanyl transdermal patches again. The case suggested that clinical pharmacists should not always reject combination use of enzyme inhibitors and enzyme substrate, should weigh the advantages and disadvantages of these kinds of drug combination according to drug properties, dosage and safety.
Keywords：CrizotinibOpioidsInteractionClinical signiifcancePrevention measure
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 286-288 )