Effect of the alcohol extract from Coreopsis tinctoria Nutt. on blood glucose and lipids in diabetic rat

LAN Yi; LU Wei; LI Lin-lin; WANG Ye; LONG Mei; MAO Xin-min

Abstract：Objective:To observe the effects of the alcohol extracts from Coreopsis tinctoria Nutt. (ECT) on the blood glucose and lipids in experimental diabetic rats. Methods:Male SD rats were fed with high glucose and high fat diet for 6 weeks, and then streptozotocin (30 mg·kg-1) was used for inducing diabetic model by peritoneal injection. The diabetic rats were randomly divided into model group, ECT treatment groups (with the doses of 0.4, 0.8 and 1.6 g·kg-1) and the metformin positive control group (0.2 g·kg-1). The normal SD rats from the same batch were used as the normal control group. The rats received daily treatment through intragastric administration for 4 weeks, and then the levels of HbAlc, insulin (Ins), fasting glucose (FBG), aspartate transaminase (AST), alanine aminotransferase (ALT), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were examined. Insulin sensitivity index (ISI), liver index and insulin resistance index (IRI) were calculated. The curve was drawn according to the results of FBG, and the area under the cueve (AUC) of FBG was calculated.Results:After 4 weeks, compared with the model group, two ECT treatment groups (with the doses of 0.8 and 1.6 g·kg-1) reduced the AUC of FBG (P<0.05). The three doses of ECT treatment groups signiifcantly decreased the levels of HbAlc, Ins, AST, ALT, TC, TG, LDL-C, IRI and liver index (P<0.01), and signiifcantly increased the levels of HDL-C (P<0.01) and ISI (P<0.05). Conclusion:ECT can improve the disturbance of blood lipids, glucose level and insulin resistence in diabetic rats.