The progress of CYP2C9 and CYP2C19 genetic polymorphisms on drug metabolism and individualized drug therapy
CHEN Hui
CAI Hong-min
FENG Duan-hao
ZHAO Guan-ren
Abstract：CYP2C9 and CYP2C19 enzymes are important drug-metabolizing enzymes involving in the metabolism of a variety of drugs in vivo. CYP2C9 and CYP2C19 genes are highly polymorphic. There are many mutations at the genetic coding and non-coding area. Functional mutations may alter the activity and elimination rate of substance drugs which might lead to drug adverse effects or toxicity. The CYP2C9, CYP2C19 gene mutation frequency and their impact on drug metabolism were reviewed.
Keywords：CYP2C9CYP2C19Genetic polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 240-243,244 )