Effect of edaravone on renal function indexes of Cr and BUN in patients with cerebral infarction

WU Zi-jing; HUANG Shu-pan; ZHANG Gao-wei

Abstract：Objective:To observe effect of edaravone on renal function indexes of blood creatinine (Cr) and urea nitrogen (BUN) in patients with cerebral infarction. Methods:A total of 130 inpatients with cerebral infarction from January to September in 2013 were collected and randomly divided into treatment group (n=65) and control group (n=65). All patients of two groups were given routine treatment for cerebral infarction. The patients in treatment group were added intravenously edaravone 30 mg besides routine treatment. The values of Cr and BUN were examined respectively before and on the 5th, 10th day after treatment. Indexes of the renal function were compared between the two groups. Results:Cr values of the both groups decreased signiifcantly after treatment. Cr values of treatment group decreased more signiifcantly compared with that of the control group on the 10th day (P<0.05). Cr values also signiifcantly decreased among 9 patients of cerebral infarction with renal insufifciency after the treatment of edaravone for 5 days (P<0.05), but showed no signiifcant differences compared between two groups (P>0.05);BUN values showed increased trend in treatment group, no signiifcant differences were found between or within groups (P>0.05). The neurologic deifcit scale (NDS) of the patients in treatment group was obviously lower than that of the control group (P<0.05), and the efifciency rate (69.6%) in treatment group was obviously higher than that of the control group (41.4%) (P<0.05). About 8 cases of elevated aminopherase and 16 cases of elevated BUN values were observed in treatment group, while 10 cases of elevated aminopherase and 8 cases of elevated BUN in control group. Conclusion:Edaravone could decrease the renal function index of Cr in patients with cerebral infarction, but had no obvious effect on BUN values, which should be authenticated by many samples, long-term observation and high quality study.