Effect of structured triglyceride on the protein metabolism of MODS patients

TIAN Ning; TIAN Hui

Abstract：Objective: To investigate the effect of structured triglyceride (STG) and MCT/LCT on the nitrogen balance and protein metabolism of patients with multiple organ dysfunction syndrome (MODS). Methods:A total of 40 MODS patients admitted to our hospital from September 2012 to February 2013 were collected and divided into STG group (n=20) and MCT/LCT group (n=20). Both groups received parenteral nutrition treatment of equal nitrogen and calories. The daily calories were required as 20 kcal·kg-1, and the daily requirement of nitrogen was calculated as 0.2 g·kg-1. Specimens were collected and tested for the balance of nitrogen and the level of serum prealbumin before TPN treatment and on the 1st, 3rd and 7th day after TPN treatment, and the treatment time of parenteral treatment was counted. Results:On the 1st day both before and after the TPN treatment, both groups showed obvious negative nitrogen balance. On the 7th day the cumulative nitrogen balance value of the STG group was (7.2 ± 2.0) g, which was obviously higher than that of the MCT/LCT group (4.0 ± 2.1) g. On the 1st day both before and after the TPN treatment, both groups had low levels of serum prealbumin. On the 7th day the serum prealbumin level of the STG group was (304.7 ± 34.9) mg·L-1, which was obviously higher than that of the MCT/LCT group (261.3 ± 32.8) mg·L-1. The treatment time of TPN in the STG group was (12.5 ± 2.4) d, which was obviously lower than that of the MCT/LCT group (15.8 ± 2.3) d. Conclusion: The STG could obviously improve the nitrogen balance, increase the level of serum prealbumin, while reduce the treatment time of TPN in MODS patients. On the aspect of improving the protein metabolism of the MODS patients, STG was much better than the physically mixed MCT/LCT fat emulsions.