Relationship between genetic polymorphisms of PXR and cyclosporine blood concentration of stable heart transplant recipients
SHI Xiu-jin
WEI Guo-yi
LIN Yang
ZHONG Yu
ZHANG Hai-bo
MENG Xu
QIN Ying
LI Xiao
BAI Yu-guo
ZHENG Qing-min
ZHOU Yang
JIA Yi-xin
Abstract：Objective: To investigate the correlation between gene polymorphisms of pregnane X receptor (PXR) and cyclosporine blood concentration in heart transplant patients. Methods:MassARRAY was applied to detect the PXR genotypes of 59 stable heart transplant recipients. AxSYM fully-automated chemistry immune analyzer was used to detect the blood concentration of cyclosporine. And then the inlfuence of the genotypes of PXR single nucleotide polymorphism (SNP) on cyclosporine trough blood concentration was analyzed by statistical method. Results:The minor allele frequency (MAF) in 8 tags of PXR SNP of 59 patients obtained in this study was similar with that in NCBI's dbSNP database of Chinese population. The blood concentration and corrected concentration of cyclosporine in PXR rs1523127 (C 24381 A) AA patients were obviously lower than those of CA patients, and those of CA patients were obviously lower than those of CC patients (P< 0.05). There was no statistical difference in the cyclosporine blood concentrations in patients with the other seven PXR Tag SNP (rs3814056T>G, rs7643645A>G, rs11917714C>T, rs2276705C>A, rs2472681T>C, rs2472682C>A, rs4440154C>T). Conclusion:There was signiifcant correlation between PXR rs1523127 (C24381A) genotype and cyclosporine blood concentration in stable heart transplant recipients, which indicated that this SNP may play an important role in the individual application of cyclosporine.
Keywords：MassARRAYHeart transplantationCyclosporineBlood drug concentrationPregnane X receptor (PXR)Genetic polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 152-155 )