Systematic review on magnesium sulphate for the treatment of acute asthma in children
MA Zhuo
FENG Wan-yu
SHI Lu-wen
Abstract：Objective: To estimate the effect of intravenous and nebulised magnesium sulphate on children with acute asthma. Methods: Published randomized controlled trials (RCTs) focused on intravenous and nebulised magnesium sulphate vs placebo in the treatment of children with acute asthma in Cochrane Library, Medline, PubMed, Embase, CNKI, VIP, CBM database were collected. The methodological quality of the included studies was evaluated and the forest plot with meta-analysis was drawn by RevMan 5.2. Results:A total of 9 RCTs were included, involving 844 patients. The results of meta-analysis revealed that compared with control group, intravenous magnesium sulphate could decrease the hospitalization rate and improve pulmonary function in children (P<0.05), but couldn't reduce the clinical symptom scores. Compared with control group, nebulised magnesium sulphate could improve pulmonary function in children (P<0.05), but couldn't decrease the hospitalization rate and clinical symptom scores. Conclusion: Intravenous and nebulised magnesium sulphate could improve some clinical indicators of acute asthma in children. However, high quality, large samples and multiple center RCTs are still required to conifrm the efifcacy and safety.
Keywords：Magnesium sulphateAcute asthmaChildrenEfifcacySystematic review
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 138-141 )