Clinical effects of nifedipine sustained-release tablets, enalapril maleate tablets and bisoprolol fumarate tablets on 24-hour blood pressure in patients withⅠgrade hypertension
ZOU Ren-min
LIU Guo-shu
XU Fu-shan
LIU Feng-mei
LI Dong-yun
WANG Liang
ZHANG Jin-jia
Abstract：Objective: To observe the hypotensive effects of nifedipine sustained-release tablets, enalapril maleate tablets and bisoprolol fumarate tablets in patients withⅠgrade hypertension. Methods:A total of 182 patients withⅠgrade hypertension were randomly divided into three groups: nifedipine group (62 patients taking nifedipine sustained-release tablets 20 mg daily), enalapril group (60 patients taking enalapril 5 mg daily) and bisoprolol group (60 patients taking bisoprolol 5 mg daily). All patients entered 4-week clinical observation with 24-hour Holter and ambulatory blood pressure monitoring after 2-week placebo induce. Results:The three drugs signiifcantly reduced casual blood pressures. After administration the blood pressure of nifedipine group, enalapril group and bisoprolol group reduced (10 ± 13) mm Hg, (19 ± 11) mm Hg and (7 ± 18) mm Hg respectively. Bisoprolol showed more hypotensive effect on 24-hour mean systolic blood pressure and daytime mean diastolic blood pressure than nifedipine and enalapril. Conclusion:Administration of nifedipine sustained-release tablets 20 mg daily, enalapril 5 mg daily and bisoprolol 5 mg daily showed signiifcant hypotensive effect. Bisoprolol was better than nifedipine and enalapril.
Keywords：HypertensionAmbulatory blood pressureMonitoringNifedipineEnalaprilBisoprolol
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 131-133,179 )