Rash, megaloblastic and hypersensitivity syndrome caused by the use of lamotrigine and valproate
MEI Xin
TONG Bo
GUO Ling-ling
LIU Li-min
Abstract：A 64-year-old male patient was given valproate (500 mg, bid) and lamotrigine (25 mg, qd) for 30 days because of epileptic recurrent seizures. The patient was admitted to hospital for fever, rash, convulsions, walking disorders. Bone biopsy test indicated megaloblastic erythrocytes. Loratadine (10 mg, qd, po), compound glycyrrhizin (60 mg, qd, ivgtt) were given and lamotrigine was stopped immediately. Valproate was administrated orally 750 mg in the morning and 500 mg in the afternoon to treat epilepsy. The condition of the patient improved after 12 days, and the patient took valproate when he was discharged from hospital. Two days later, the patient was admitted to hospital because of the aggravated rash and fever. Methylprednisolone (40 mg, bid, ivgtt), loratadine (10 mg, qd, po) and compound glycyrrhizin (60 mg, qd, ivgtt) were given immediately, the valproate was stopped, and the phenobarbital (100 mg, bid, im) was given to treat epilepsy. After 20 days, phenobarbital injection was adjusted with oral dosage form (30 mg,bid,po). The fever and rash disappeared, while the liver function of the patient recovered, ifnally the patient discharged on the 22nd day.
Keywords：LamotrigineValproateEpilepsyRashHypersensitivity syndrome
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 125-126,127 )