The effect of intra-articular injection of recombinant human tumor necrosis factor-Fc and compound betamethasone in knee in patients with rheumatoid arthritis
MA Hua
ZHANG Hong
DENG Xiao-hu
Abstract：Objective:To evaluate the efifcacy and safety of intra-articular injection of recombinant human tumor necrosis factor-Fc and compound betamethasone in patients with knee arthritis of rheumatoid arthritis (RA). Methods:A total of 24 patients with knee arthritis of RA were intra-articular injected recombinant human tumor necrosis factor-Fc 25 mg and compound betamethasone 7 mg. Visual analogue scale (VAS), swelling scores, tenderness scores, the thickness of synovium were recorded and analyzed at 4-week as well as 8-week treatment after injection compared with pre-treatment. Results: Compared with that of pre-treatment, the VAS, swelling scores, and tenderness scores signiifcantly improved after treatment for 4 weeks and 8 weeks (P<0.05). The average thickness of synovium in knee at 4-week and 8-week treatment were (5.8 ± 2.2) mm, (4.2 ± 2.3) mm respectively, which showed signiifcant differences compared with that of pre-treatment (6.7 ± 2.0) mm (P<0.05). Conclusion:Intra-articular injection of recombinant human tumor necrosis factor-Fc and compound betamethasone is an effective and safe therapy for refractory knee arthritis of RA.
Keywords：Intra-articular injectionRheumatoid arthritisRecombinant human tumor necrosis factor-FcCompound betamethasoneTreatment
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 65-67 )