Application analysis of caspofungin used in 156 patients in our hospital

YANG Ya-qing; ZHANG Xiao-xue

Abstract：Objective: To survey the application of caspofungin in our hospital and provide reference for rational use in clinic. Methods: A total of 156 cases using caspofungin were extracted from January 2011 to March 2012 and retrospectively analyzed in respect of the number of use of caspofungin in different wards, situation of medication, clinical efifcacy and adverse reactions. Results:Among 156 cases of application of caspofungin, the usage and administration in 141 cases complied with the speciifcation of caspofungin, the loading doses and maintenance doses in 3 children patients were reduced, both of the maintenance doses and loading doses in other 12 cases were 70 mg. The highest frequent use of caspofungin was respiratory department (38 cases, accounting for 24.36%), followed by hematology department (31 cases,accounting for 19.87%) and cardiovascular department (17 cases, accounting for 10.90%). After application of caspofungin treatment, the total effective rate was 51.93%, and in the course of treatment no serious adverse reaction was found. Conclusion:Caspofungin was relatively safe and effective for the treatment of invasive aspergillosis, invasive candidiasis as well as candidemia.