Retrospective analysis of 101 ADR reports associated with ciprofloxacin

WEN Ai-ping; JIA Guo-qiang

Abstract：Objective:To investigate the characteristics and clinical manifestations of adverse drug reaction (ADR) related to ciprolfoxacin, and provide references for clinical rational drug use. Methods: Using retrospective analysis, a total of 101 ADR case reports collected from Beijing Centre for ADR Monitoring from January 1, 2007 to December 31, 2011 were statistically analyzed in respect of gender and age of patients, utilization of drug use, organs and systems involved in ADRs as well as clinical manifestations, etc. Results:Among the 101 ADR cases, 42 cases (41.58%) were male and 59 cases (58.42%) were female, the average age of the patients was (55.03 ± 18.11) years. Ninety-seven ADR cases were caused by intravenous injection (96.04%). The ADRs involved in 10 organs/systems, with the most frequent in skin and its appendages (38.69%), followed by application site disorders (18.98%), nervous system disorders (16.79%), gastrointestinal system disorders (10.22%), etc. There were 5 cases of serious ADRs, with the manifestations of allergic shock (2 cases), toxic epidermal necrolysis (2 cases) and acute renal failure (1 case). Conclusion: The ADRs induced by ciprolfoxacin could involve in multiple organs/systems. Ciprolfoxacin should be used strictly according to the drug instructions and regulations, while monitored intensively in order to avoid or reduce the occurrence of ADRs.