Study on the factors affecting the stability of dexamethasone in Shengfu frost and the optimization of its formulation
ZHAO Wei-juan
ZHANG Mei
WANG Jin-pin g
Abstract：Objective:To investigate and eliminate the factors affecting the stability of dexamethasone in Shengfu frost, and optimize its formulation. Methods: The dispersible uniformity test and the high temperature destruction test were carried out for quantitative analysis of the factors affecting the stability of dexamethasone, on the basis of which we optimized the formulation and process. Results:The study showed the content of dexamethasone would decrease apparently, when the pH level of the matrix was higher than 7.3. The solubility of dexamethasone was low in highly polar solvents, which was the main factor of heterogeneous dispersion. Dissolving dexamethasone in appropriate amount of laurocapram before the preparation will make the dispersion uniform. The content of dexamethasone could be stable when the pH level of the matrix was between 5.5 and 6.5. Conclusion:The accelerated destruction test and the solubility test were adopted for comprehensively analyzing the factors which affected the formulation stability. The method is reasonable and suitable for the quick investigation and optimization of formulations.
Keywords：Shengfu frostDexamethasoneInlfuence factorsFormulation optimization
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )