Analysis of irrational antibacterials prescriptions based on the PK/PD theory of antibacterial drugs in the outpatient dispensary of our hospital
XIE Ting-ting
ZHU Man
REN Hao-yang
Abstract：Objective:On the basis of PK/PD theory for antibacterials, the irrational prescriptions of antimicrobials were analyzed in the outpatient dispensary of our hospital in order to optimize clinical dosing regimens. Methods:Based on 4 cases of irrational antibacterial prescriptions with higher frequency, combined with PK/PD theory, the evaluating strategies were clariifed, such as the application of antibacterials indications, usage, dosage, drug frequency and so on. Results: β-lactam antibacterials were time-dependent antibacterials, T>MIC of which must be more than 40%interval time of administration for good antibacterial effect. Azithromycin tablet was macrolide antibacterials with time-dependent and long PAE, the dosing frequency of azithromycin was recommended as once a day. Fluoroquinolones were concentration-dependent antibacterials with higher tissue concentration, whose AUC0-24 h/MIC≥100 and/or Cmax/MIC>8 were necessary for good antibacterial effect. Conclusion:During the process of prescription analysis, pharmacists should evaluate the comprehensive conditions of patients, carry out effective prescription comment with the guidance of the PK/PD theory of antibacterials and actively provide effective intervention in order to promote clinical rational drug use.
Keywords：Outpatient prescriptionsAntibacterialsAnalysis of prescriptionsRational drug use
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 323-324,325 )