Elevated blood pressure caused by intravenous drop administration of levofloxacin
LV Juan-li
WANG Nan
LIU Zhen-hua
Abstract：A 75-year-old woman, hospitalized for bacterial pneumonia and pulmonary shadows with unknown origin, was administrated with intravenous drip infusion of levolfoxacin-sodium chloride injection 600 mg at the infusion rate of 1.5 mL· min-1 once daily. The patient suddenly had headache, chest tightness, nausea and vomiting after infusion. The results of general examination showed that the body temperature was 38.6 °C, blood pressure was 160/80 mm Hg, respiratory rate was 20 breaths per minute, and heart rate was regular with 82 beats per minute. Then captopril tablet 12.5 mg was given by sublingual administration immediately, and nifedipine sustained-release tablet 10 mg was administrated orally. The blood pressure decreased slightly, but it increased again next day. The levolfoxacin injection was stopped and she recieved cefminox for anti-infective therapy, the patient's BP gradually returned to normal value. Due to the poor effect of anti-infection, the patient was administrated with levolfoxacin injection (300 mg, ivgtt, qd). Nifedipine sustained-release tablet (10 mg, bid) was also used for controlling blood pressure. Seven days later, the value of blood pressure rose up again. Although the double dosage of nifedipine was used, the blood pressure lfuctuated in the high range during the next six days. Levolfoxacin was discontinued, three days later, the patient's blood pressure returned to normal, after that the blood pressure did not raise again.
Keywords：LevolfoxacinElevated blood pressureAdverse drug reaction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 300-301 )