Pseudohyperaldosteronism caused by compound glycyrrhizin tablets
ZHANG Ying
YU Gang
WANG Yan-yan
ZHAO Wei
ZHANG Jiang-lin
Abstract：One 51-year-old male patient with psoriasis arthritis developed elevation of AST and ALT and received compound glycyrrhizin tablets (2 tablets, tid) for the treatment of drug-induced hepatitis, which caused by methotrexate. After a week of the treatment, the patient developed weakness in lower legs and hard walking. After 2 weeks, he appeared edema in the face and lower extremity, and the blood pressure increased to 160/90 mm Hg. He suffered from upper limbs weakness and shivering, and the blood pressure was 160/90 mm Hg after 3 weeks of the treatment. After stopping use of compound glycyrrhizin for one week, the symptoms of weakness, hard walking and upper limb shaking relieved, the blood pressure returned to 130/76 mmHg, while the patient appeared hypokalemia with blood potassium 1.76 mmol?L-1 and metabolic alkalosis. The combination use of medication was not found. The functions of thyroid and adrenal were normal. After the treatment of potassium supplementation for 5 days, blood potassium recovered to 4.22 mmol?L-1, metabolic alkalosis was corrected.
Keywords：Compound glycyrrhizinHypopotassemiaPseudohyperaldosteronismAdverse drug reaction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 298-299 )