Evaluation of antidepressant effect and protective effect against corticosterone-induced PC12 cell injury of icariin
SHI Cui-ge
LI Hui
WANG Li-li
WANG Ning
WANG Jie-dong
ZHANG Shu-cheng
XU Zhi-qing
Abstract：Objective:To investigate the antidepressant effect and the protective effect against corticosterone-induced PC12 cell neurotoxity of icariin. Methods:The antidepressant effects of icariin were evaluated by the tail suspension test in mice and the forced swimming tests in rats and mice. The animals were divided into four groups randomly:control group, low dose icariin group, high dose icariin group and amitriptyline group. The effects of icariin on immobility time were measured in the forced swimming test in rats and mice, together with the tail suspension test in mice. Likewise, PC12 cell injury model was induced by corticosterone and the protective effect of icariin on the cell viability was measured by MTT assay. Results:Icariin could signiifcantly decrease the immobility time in tail suspension test in mice, as well as the forced swimming tests in rats and mice, with the signiifcant differences when compared with the control group. In addition, icariin could improve the survival rate of PC12 cells injuried by corticosterone. Conclusion:Icariin possessed antidepressant effect and its antidepressant effect maybe involve in the protective effects of neural cells.
Keywords：DepressionIcariinCorticosteroneImmobility time
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 268-270 )